HORDB

ID: hor002686
Uniprot ID: Q19569
Protein name: NLP-7
Gene name: nlp-7
Organism: Caenorhabditis elegans
Family: NA
Source: animal
Expression: Up-regulated when diet is restricted.
Disease: NA
Comments: NA
Taxonomy: Caenorhabditis (genus), Peloderinae (subfamily), Rhabditidae (family), Rhabditoidea (superfamily), Rhabditomorpha (infraorder), Rhabditina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0008340 determination of adult lifespan; GO:0061771 response to caloric restriction; GO:1901046 positive regulation of egg-laying behavior; GO:1901562 response to paraquat
GO CC: NA

Sequence: QADFDDPRMFTSSF
Length: 14(27-40)
Propeptide: MYIKAALLIVVLFGVASQITSALYLKQADFDDPRMFTSSFGKRSAIESEPQAYPKSYRAIRIQRRSMDDLDDPRLMTMSFGKRMILPSLADLHRYTMYDKRGSDIDDPRYFLFSNRLTCRC
Signal peptide: MYIKAALLIVVLFGVASQITSA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: May regulate lifespan in response to food availability and oxidative stress.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002686_AF2.pdb

hor002686_ESM.pdb

Mass:	189583	Formula:	C73H102N18O25S
Absent amino acids:	CEGHIKLNVWY	Common amino acids:	DF
pI:	3.83	Basic residues:	1
Polar residues:	3	Hydrophobic residues:	4
Hydrophobicity:	-73.57	Boman Index:	-4289
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	7.14
Instability Index:	1502.14	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 20013198
Title: Approaches to Identify Endogenous Peptides in the Soil Nematode Caenorhabditis elegans